Integrative analysis of haplotype-resolved epigenomes across human tissues (2015) Nature

February 20, 2015

Understanding individual specific gene regulation mechanisms is critical in personalized medicine era. However, the effect of individual specific genetic background on gene regulation is still unclear. We generate haplotype-resolved epigenomic maps across broad human tissue types with multiple individuals through a chromosome-spanning haplotype reconstruction strategy. The maps revealed individually restricted extensive allelic biases in chromatin state and transcription. 


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